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Indeed, current guidelines do not recommend administration of PDE5i to patients with unstable angina, severe congestive heart failure, or uncontrolled hypertension, patients at high risk for arrhythmias, and patients receiving nitrates [13]

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In this context, acceptance of, adherence to and persistence with medical and behavioural interventions to support cardiorenal health, cardiovascular risk reduction and attainment of glycaemic and weight goals will prevent complications and optimise quality of life