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FOXO4-DRI's D-retro-inverso structure gives it extended half-life compared to standard L-peptides, meaning each injection provides sustained p53 displacement activity

Many pharmaceutical companies have tried to develop drugs that target Mcl-1, but this has been difficult because the interaction between Mcl-1 and its target protein occurs in a long stretch of 20 to 25 amino acids, which is difficult to block with the small molecules typically used as drugs

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Others may have temporary symptoms such as mild nausea, headache, or mild dizziness