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The stratified analysis emphasizes the importance of individualized counselling before initiating diabetic agents in patients with a history of herpes infections

Discussion We have conducted the largest real-world retrospective cohort study to date investigating the safety and outcomes of individuals with type 1 diabetes using SGLT2i and GLP-1 RA therapy, and the first to report cardio-renal benefits

Having a diagnosis of a substance use disorder confers an increased all-cause mortality in populations with diabetes across a range of substances, including cocaine, opioids and cannabis, regardless of consumption

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However, important limitations exist when considering GLP-1 therapy specifically for IBS management