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10.1073/pnas.0806720106 78 LockieS

Development of GLP-1 receptor agonists The most important strategy to develop compounds with extended in vivo half-life of GLP-1 was by making DPP-4 resistant GLP-1 receptor agonists

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A 2023 analysis of over 16,000 patients found that individuals taking GLP-1 medications reported improvements in depressive symptoms, though the exact mechanism remains under investigation