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The majority of findings rely on in vitro experiments and animal models, which limits the ability to generalize results beyond controlled research environments

Our findings do not exclude a positive role for endosomal signaling or -arrestin-1 recruitment in acute responses to physiological GLP-1, but highlight how the kinetic context must be taken into account when exploiting noncanonical pathways during drug development

The first GLP-1 injectable receptor agonist exenatide was approved by the U.S

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