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Inflammatory pathways are deeply entrenched

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However, the CNS is exposed to many situations that can induce a cell and tissue damage associated with ROS production

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FOXO4-DRI alleviates testosterone secretion insufficiency in naturally aged mice Our finding that FOXO4-DRI targeted senescent TM3 Leydig cells in vitro prompted us to investigate its therapeutic effect in vivo using naturally aged (20-24 months) male mice as subjects