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This A deposition first emerges in the subiculum area of the hippocampus and in the layer 5 of somatosensory cortex, and then rapidly increases with age, spreading to fill much of the hippocampus and cortex by 9 months of age ( By performing acute A applications ex vivo , the authors proposed that soluble A might trigger the decrease of synaptic plasticity in neocortical pyramidal cell networks during early stages of AD pathogenesis by preferentially targeting postsynaptic AMPA receptors ( NMDAR in Plasticity and Network Performance Many forms of plasticity, including some forms of STDP, require the activation of glutamate NMDA-type receptors (NMDAR) ( in vivo ( Glial Involvement in Promoting Network Activity or Its Disruption In addition to neurons, glial cells are also involved in the control of synaptic transmission, synaptic plasticity and neuronal synchronized activity ( in vivo stimulation of fast-spiking interneurons at frequency altered microglia morphology inducing a shift from pro-inflammatory to phagocytic phenotype that resulted in a significant reduction of the amyloid load in 5xFAD mouse model and improved network performance ( Discussion The exact cellular mechanisms at the root of plasticity changes during brain development in the course of the progression of aberrant network activity leading to cognitive dysfunction in AD remain elusive

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AJR Am J Roentgenol 172:12931296

Severe adverse events would theoretically be reversible upon discontinuation in most cases