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However, these compounds are associated with Nrf-2-independent adverse effects, which prevented their clinical use despite their beneficial induction of glutathione synthesis

Adverse effects such as nausea, vomiting, and gastrointestinal discomfort remain common, but usually diminish with time and proper dose escalation

As women move through perimenopause and menopause, insulin resistance becomes more common and contributes to weight gain, inflammation, and fatigue

Results vary depending on factors such as genetics, hormones, stress levels, and overall health

The filing comes amid increasing scrutiny of potential vision-related side effects linked to GLP-1 receptor agonists