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coli ) and 40-fold (human gut bacteria) coverage of their genomes, and sequencing depths per base were calculated from the reads using SAMtools ( Gini coefficients of SAGs were calculated from mean sequencing depths per 50-kb bin using the R ineq package

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation