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B = National unadjusted copayment for APC/national unadjusted payment rate for APC

For an early-stage acquisition where the targets asset has not yet reached Phase III, an earn-out can defer 40-60% of the total consideration to milestones including Phase III initiation, Phase III readout, NDA submission, approval, and first-year revenue thresholds

Notably, Amuc_1409 exhibits a unique mode of action in modulating intestinal stem cell function, representing the first reported bacterial secreted protein capable of enhancing intestinal stem cell-mediated regeneration [100]

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