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As a broad melanocortin receptor agonist active at MC1R, MC3R, MC4R and MC5R, it engages a wider receptor profile than Melanotan I, making it one of the most mechanistically versatile melanocortin compounds available for pigmentation, appetite and sexual-function signalling research in 2026

doi: 10.1038/s41392-022-01190-w 122 VitielloPPCardoneCMartiniGCiardielloDBelliVMatroneNet al

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These studies reveal that GLP-1 RAs not only decrease oxidative stress and inflammation in endothelial cells but also inhibit cardiac hypertrophy and fibrosis by regulating myocardial proliferation and apoptosis [76]

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M et al