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GLP-1RAs are also being explored in ongoing trials in people at risk for diabetic kidney disease, people with HFpEF, people with NASH and individuals with peripheral artery disease (Fig

Reinforcing this, in heart failure with preserved ejection fraction, randomized trials such as the STEP-HFpEF program published in the New England Journal of Medicine demonstrated improvements in symptoms and physical limitations, with benefits that could not be fully explained by weight loss alone

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