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Conversely, AR inhibition leads to marked reduction of de novo lipogenesis and permits incorporation of dietary FA enriched in polyunsaturated FA which are prone to lipid peroxidation when subjected to oxidizers such as arsenic trioxide (60, 61)

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MCTs may cause accelerated MCFA oxidation and promote the production of acetyl CoA, which can be a substrate providing carbons for chain elongation and FA synthesis (Figure 1)

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Detoxification The effectiveness of NAC as an antidote to paracetamol poisoning is based on its ability to restore GSH levels in the liver and to act as an alternative substrate for conjugation of toxic paracetamol metabolites