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Inhibiting inflammatory markers including cytokines (including IL-6 and TNF-), nitric oxide, and reactive oxygen species is how Ashwagandha reduces inflammation, according to preclinical studies

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Additionally, arachidonic acid-15-lipoxygenase (ALOX15) knockdown or treatment with the lipoxygenase inhibitor baicalein has shown protective effects against ischemic brain damage in murine models (45)

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