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A landmark 68-week randomized controlled trial found that once-weekly semaglutide combined with lifestyle intervention produced a mean body weight reduction of approximately 14.9% compared to approximately 2.4% with placebo

This next study may be imperfect, too, but it is likely to bring us closer to better understanding the degree of risk for blindness that may be associated with these medicines.

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Some describe early satiety (feeling full quickly) or reduced interest in food, particularly high-fat or sweet items

The clinically meaningful difference between the two is that semaglutide activates one receptor (GLP-1), whereas tirzepatide activates two (GLP-1 and GIP), which tends to make it more effective for weight loss