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This aberrant activation promotes excessive phosphorylation at the Ser396, Ser404, and Thr231 sites of tau, ultimately driving its pathological aggregation [138]

The broader pharmaceutical industry continues to grapple with global pricing reforms and the integration of AI, adding layers of complexity to market dynamics.

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In subgroup analyses, no difference in effect was detected between trials performed with different molecules of the class, or between studies performed on subjects with a mean baseline BMI higher or lower than 35 kg/m 2 ( p = 0.91 and p = 0.16 for difference between different molecules, respectively, Figures 1 and S6)