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The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism
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Tumor-intrinsic studies provide convergent, mechanistic evidence that the m 6 A reader YTHDF1 curtails antigen visibility: loss of YTHDF1 in cancer cells limits the translation of lysosomal genes, reduces lysosomal proteolysis of MHC-I and tumor antigens, upregulates surface MHC-I, and converts immunologically cold tumors into hot ones that respond to checkpoint blockade