GLP-1 agonists work by mimicking the glucagon peptide-1 hormone which slows down gastric emptying and helps you feel fuller for longer
Study: Glucagon-like peptide-1 receptor agonists and major limb events in adults with type 2 diabetes and peripheral artery disease: a systematic review and meta-analysis of RCTs and cohort studies
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These were patients on medications, so a 9.5 mmHg improvement was more than was predicted. In terms of side effects, one-quarter of people taking tirzepatide in both studies experienced gastrointestinal side effects like nausea, vomiting, and constipation, which often diminished over time
Tirzepatide: Unlike a semaglutide, this peptide is a dual agonist