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A clinical proof-of-concept trial used 0.03 mg/kg twice daily for short durations and found the drug to be generally well tolerated, though efficacy endpoints were mixed depending on the indication

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Oxidative stress causes membrane phospholipid rearrangement and shedding from RBC membranes - an NMR study

Cardiovascular Effects Blood Pressure and Circulation PT-141 is known to cause temporary spikes in blood pressure, which may be problematic for women with hypertension, migraines, or cardiovascular conditions

"This study highlights that treatment discontinuation, especially early, negatively affects both weight and glycemic control outcomes." A follow-up study is in the works to better track why patients stop taking their GLP-1 drugs, researchers said