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Discussion Despite recent advancements in cardiovascular prevention and treatment, cardiovascular disease remains the leading cause of death worldwide, particularly among high-risk populations such as those with type 2 diabetes and/or hypertension [1]

These figures havent been established in human trials, and long-term human safety data doesnt exist

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"High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia"

Rather than generating a dopamine-driven reward response, many patients report that sweets taste overly intense, leave an unpleasant aftertaste, or trigger nauseaespecially at higher semaglutide doses