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DNA damage leads to the activation of p53/p21 or p16, resulting in the halting of proliferation and induction of senescence in cancer cells [60]

Eat Small, Frequent Meals Avoid large meals and opt for smaller, more frequent meals to ease digestive processes

Converting that hypothesis into knowledge requires PCOS-specific clinical trials with metabolic and reproductive endpoints, adequate duration, and rigorous attention to fertility and pregnancy safety

The Binge Trigger: For many, the 16-hour fast leads to such intense hunger that they overeat during the 8-hour window

Espinoza N, Papadopoulos V (2025) Role of mitochondrial dysfunction in neuropathy