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Similar to the story of GLP-1 drugs, the weight loss effects of targeting glucagon and GIP could have only been achieved with drugs that could chronically activate hormone receptors across the body, drugs with effects that are more potent and widespread in the body than the natural hormones that are secreted
One regulatory context that's worth understanding before you subscribe: on January 6, 2026, the FDA issued updated guidance (General Wellness: Policy for Low Risk Devices, superseding its 2019 version) that explicitly clarifies which digital health products fall outside medical device oversight
The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible
The decision is individualized based on the patients contraception needs, pregnancy risk, and tolerance for unplanned pregnancy
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