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The most common single variant reported in relation to cancer was the methionine synthase MTR A2756G (rs1805087) (chromosome 1q43), which is an A-to-G transition at base-pair 2756 and leads to a change from aspartic acid to glycine at codon 919 (D919G)

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What the percentages actually mean in real terms Percentages can feel abstract

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That depends on your goals, medical history, and risk tolerance