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The resulting disturbed environment promotes microglial activation, which is associated with glutamate release in the spinal dorsal horn, further amplifying central sensitization (Kawasaki et al

Research has shown that GLP-1, along with other gut-brain peptides like ghrelin, leptin, and galanin, acts on the mesolimbic dopamine system of the brain and influences the activation of this system by alcohol and other addictive drugs