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In a presentation (PDF) to investors, Zealand notes that nearly 70% of clinical trial participants on the highest dose reported no gastrointestinal adverse events at any time
Changes related to fat metabolism or body composition typically take longer and are usually noticed after 34 weeks of consistent use, especially when combined with a healthy diet and activity plan
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Long-term effects: Long-term safety of retatrutide at high doses outside of controlled trials is not fully researched
Do not apply this at the same time as an acid serum or cream
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