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In the study Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin , it was found that providing calcium supplementation to people taking metformin, was able to help prevent metformin-induced vitamin B12 deficiency

This approach maintains more consistent peptide levels throughout the day and may provide advantages for individuals using doses at the higher end of the range (450-500mcg daily)

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Among the three cohorts, only the LUMHS cohort demonstrated a balanced gender distribution across the groups (Pearsons Chi-square test