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Although the degree of inflammation in OA is generally lower than in rheumatoid arthritis, synovial tissue can still exhibit marked hyperplasia and inflammatory cell infiltration (1)

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Bluish or gray to black appearance Usually small papule Common sites include dorsum of foot, wrist, and head Usually oval-shaped lesion in reticular dermis Composed of slender fusiform and dendritic melanocytes, usually heavily pigmented with associated melanophages Stromal fibrosis is common Periadnexal growth is common Nerve involvement may be seen The sclerosing BN is characterized by prominent stromal fibrosis

NMN 250 mg orally daily vs placebo

Figure 1 provides a summary of the pathways and demonstrates which pathways are targeted by the better studied treatments