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A licensed healthcare practitioner who is capable of determining the correct dosage and ensuring safe administration should administer these injections

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The Veteran Affairs-Diabetes in Nephropathy Study (VA-NEPHRON-D) and Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (ALTITUDE) trials similarly assessed combination RAAS blockade but were discontinued early due to increased rates of hyperkalemia, AKI, and hypotension [88,89]

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