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4), we had identified an active chloroacetamide ( 7 , IC 50 JAK3 = 30.3 11.2 nM, IC 50 BTK = 170.3 40.6 nM) and a moderately active methyl-substituted chloroacetamide ( 8 , IC 50 JAK3 = 388.3 149.1 nM, and with no BTK activity at 1 M)

[(accessed on 5 June 2025)]