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Left ventricular dysfunction should be managed with agents that provide afterload reduction (eg, angiotensin converting enzyme inhibitors) and have been shown to enhance survival in non-ESRD patients

Since direct, in vivo measurements of ROS are difficult due to their short half-lives, the only way to evaluate the level of oxidative stress is based on indirect quantification of the levels of DNA damage, peroxidation of membranes, and protein modification

However, this does not mean you should skip doses or stop treatmentgradual adaptation is normal

X., et al., Body Weight Management in Overweight and Obese Breast Cancer Survivors, Cochrane Database of Systematic Reviews 12 (2020): Cd012110