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In accordance with this, studies where iron accumulation was forced in tumor cells, either by overexpression of TFR1 or through iron-rich nutrition, demonstrated enhanced tumor growth [65, 66]

PMID: 7 FerrazEBorgesMCTerra-FilhoJMartinezJAViannaEO

Although not evaluated here, lower intracellular GSH levels would also deactivate the GSH-dependent GPX4, further enhancing ferroptotic cell death (8, 38)