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(102) demonstrated that pretreatment with Ex-4 for a week, induced tolerance to cerebral ischemia that lasted for at least 6 days in the mouse brain after MCAO and this neuroprotective state was related to upregulation of IGF-1R which was mediated by GLP-1R and, following by activation of the IGF1R-regulated the PI3K/AKT/mTOR/HIF-1 pathway by binding to IGF-1

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Since GHK-Cu levels decline naturally with age, ongoing supplementation helps maintain the gains achieved during intensive treatment phases

BPC-157 has no published human safety data beyond anecdotal reports and animal studies, which makes any safety characterization incomplete