How to Taper Off GLP-1 Medications: Stopping, Switching, and Preventing Weight Regain At a glance Weight regain risk / ~two-thirds of lost weight returns within 1 year of abrupt discontinuation (STEP-1 extension) Semaglutide 2.4 mg peak loss / 14.9% mean body weight at 68 weeks (STEP-1, N=1,961) Tirzepatide 15 mg peak loss / up to 20.9% mean body weight at 72 weeks (SURMOUNT-1, N=2,539) SURMOUNT-4 maintenance finding / continuing tirzepatide vs
Fatigue: Adjustments in metabolism and appetite suppression may contribute to temporary fatigue
This dual hormone approach makes Tirzepatide highly effective for diabetes management and weight loss
Thyroid hormone dosing is often related to body weight
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