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The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities

One injection per week is simpler than seven

Liraglutide (Victoza, Saxenda): Also approved by the FDA for weight loss, but requires daily injections to see results

Methods Animals and ethics statement Eight-week-old male C57BL/6 mice were obtained from the Oswaldo Cruz Foundations Animal Breeding Center

Note that in the majority of the participants, the weight loss obtained is well above 5% of the initial weight (the minimum associated with an improvement in health) and even exceeds 20% in many of them, in particular in the participants who received tirzepatide