Petersburg, Russia Initial research in 1980s at Institute of Bioregulation and Gerontology Derived from studying pineal gland peptides and aging Over 40 years of Russian research (but limited Western studies) Inspired by observation that pineal gland function declines with age Why developed: Soviet/Russian focus on longevity research Searching for ways to extend healthy lifespan Understanding cellular aging mechanisms Pineal gland's role in aging and circadian rhythms Goal: Create synthetic peptide mimicking natural bioregulators Epithalon vs epithalamin: Epithalamin: Natural polypeptide complex from pineal glands (bovine) Epithalon: Synthetic tetrapeptide mimicking epithalamin's active component Epithalon more practical (synthetic production, consistent quality) Both target similar anti-aging pathways Learn peptide fundamentals and how peptides work at SeekPeptides to understand Epithalon's unique mechanisms
CJC-1295 and ipamorelin are commonly used together because they have complementary time-release characteristics: CJC-1295 is effectively GHRH that has been modified to have a longer half-life, so it stimulates pituitary growth hormone secretion in a sustained manner over an extended period.9 Ipamorelin acts on the pituitary gland directly, inducing a more immediate dump of growth hormone into circulation
doi:10.1016/j.fertnstert.2006.03.057 Zheng SH, Chen XX, Chen Y, Wu ZC, Chen XQ, Li XL
Where is the evidence for that
In age-related diseases and more particularly in IPF, mice treated with FOXO4-DRI display less senescent cells leading to a reduction of the progression of fibrosis 28
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