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Riboflavin kinase deficiency (OMIM # 613010) RFK (EC 2.7.1.26) is a ubiquitous rate-limiting enzyme that catalyzes the first step in flavocoenzyme biosynthesis by phosphorylating riboflavin to form FMN, an obligatory step in riboflavin metabolism

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NAC raises glutathione levels (depleted glutathione levels have been associated with higher levels of thyroid antibodies) and prevents oxidative damage

In M2 macrophages, the pathway of glutaminolysis -ketoglutarate (-KG) complete TCA cycle/oxidative phosphorylation (OXPHOS) is a decisive metabolic feature that supports their anti-inflammatory function