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Structure assignment was based on mass accuracy of ions elected by OPLS-DA

In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups

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5C), this effect did not reach significance ( p = 0.069), and nor was there an impact of either NMN or Dox treatment on the reduced equivalent NADH (Fig