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Serious adverse events causing headache (pancreatitis, gallbladder disease, cerebrovascular events) are rare but distinguishable by accompanying symptoms: pancreatitis presents with severe abdominal pain radiating to the back, gallbladder disease includes right upper quadrant pain and nausea after fatty meals, and cerebrovascular events include sudden-onset severe headache (thunderclap), vision changes, weakness, or speech difficulty

People who travel a lot or move the medicine around need to follow storage guidelines

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Side effects are experienced against this emotional backdrop