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Decreased availability of glutamate limits anaplerosis of the TCA cycle, resulting in low mitochondrial respiration, and nitrogen source, resulting in the high dependency on exogenous non-essential amino acids

Therefore, Gln deficiency has led to immune dysfunction and HA overproduction in people at high risk of COVID-19

Severe tears requiring surgery represent a different situation where peptides might support post-surgical healing rather than replacing surgical intervention

References Abrahams, M., OGrady, R., & Prawitt, J

Quality evidence and better-defined outcomes are paramount to guide the selection of patients for combined therapy