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Studies have also demonstrated changes in other inflammatory markers, including fibrinogen, plasminogen activator inhibitor-1 (PAI-1), and various adhesion molecules involved in vascular inflammation

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2000 in Hormone Research showed that 21-day oral AOD-9604 (500 mcg/kg/day) reduced body weight gain by roughly 50% in obese Zucker rats with no insulin sensitivity penalty

While these mechanisms are not known to directly initiate carcinogenesis, it's important to note that long-term human data remain limited

These trials show that many people can lose large percentages of weight on this drug even in structured studies