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Our findings support several key clinical and regulatory imperatives
Mitochondria: dynamic organelles in disease, aging, and development
It is thought that Minocyclines neuroprotective properties may result from inhibition of NO-mediated neurotoxicity (Du et al., In rodents, Minocycline blocked MPTP-induced degeneration of DA neurons in the SNpc, preventing loss of striatal DA, and its metabolites (Du et al., in vivo and potently blocked NO-induced neurotoxicity in vitro (Du et al., Drosophila model of PD (Faust et al., 2010)
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