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It was originally made as a drug to help treat certain skin conditions

Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells

Interestingly, the reduction in HbA1c was already evident after the first 4 weeks of treatment and remained statistically significant up to the end of the 52-week observation period, supporting the evidence of rapid efficacy of the drug and great durability, which was independent from weight loss

Our review highlights the critical importance of further investigation into the roles of active natural constituents and their derivatives in addressing liver diseases, thereby advocating for enhanced efforts to initiate human clinical trials to substantiate their therapeutic potential