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In REDEFINE 1 (overweight/obesity without T2D), CagriSema achieved mean weight reductions of 20.4-22.7% (vs 2.3-3.0% placebo) at 68 weeks, with 53.6% and 34.7% of patients achieving 20% and 25% weight loss, respectively

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It has to tolerate food, interact with the microbiome, maintain a protective barrier, and respond appropriately to pathogens or injury

The LR3 variant includes modifications that reduce binding to IGF-binding proteins, allowing the peptide to remain active on cell receptors for a longer period during experimental procedures

Who should administer HYCOMIN and what are the precautions