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selectively overexpressed SLC7A11 in the myocardium and found that it can increase cellular GSH levels and prevent FTH deficiency-mediated iron death [76]

Due to its lipophilic nature, Mel easily penetrates cell membranes and acts as a potent antioxidant by scavenging hydroxyl and peroxyl radicals.15 This antioxidant effect is mediated through increased activity of Glutathione Peroxidase (GSH-Px) and Superoxide Dismutase (SOD), prevention of Catalase Reduction (CAT), and inhibition of Nitric Oxide Synthase (NOS)

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Another probiotic Lactobacillus casei Zhang significantly upregulated the Bacteroidetes population, a prominent butyrate producer in CKD treated mice (Zhu et al., 2021)

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