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As tirzepatide was compared to controls, the hazard ratios for MACE-4 were 0.80 (95% confidence interval [CI], 0.571.11), cardiovascular death was 0.90 (95% CI, 0.501.61), and all-cause death was 0.80 (95% CI, 0.511.25) [2]
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& Jamialahmadi, M
For instance, declines in butyrateproducing bacteria ( Faecalibacterium and Akkermansia ) diminish short-chain fatty acid production, thereby weakening PPAR-mediated keratinocyte differentiation and anti-inflammatory effects
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