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Moreover, there is significant granularity within bias, as a G protein-biased ligand may selectively activate some G proteins and not others, and a -arrestin-biased ligand may selectively activate some arrestin functions, such as internalization or signaling, and not others, such as desensitization [8991]

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293 In a mouse model of Barretts esophagus, feeding an HFD was observed to promote dysplasia and carcinogenesis by modulating the esophageal microenvironment and gut microbiome, thereby inducing inflammation and promoting stem cell proliferation

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