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Int ., 32 , No, 2, 331-334 (2012)

Wadden TA, et at

NHS eligibility criteria under NICE TA875 are more restrictive than the MHRA licence, with specific BMI thresholds and service requirements

For example, a patient carrying loss-of-function GIPR variants may respond better to semaglutide monotherapy than to tirzepatide dual-agonist formulas, allowing cost optimization toward the lower-priced compound