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The upregulated metabolites included Bhos#36, armillaripin, -Glutamylcysteine, 19-oxodesacetylcinobuf-agin, chlorophyll, WithaferinA, JP83, L-proline, trans-cinnamic acid (TCA), indoleacrylic acid, ammonia aspartate,[(2s,4R,5R,6R,14S,16R)-14-hydroxy-7,11-dimethyl-6-(2-OXOPYRAN-4-Y-L)-3-oxapentacyclo[8.8.0.02,4.02,7.011,16] octadecan-5-yl] acetate, PGP (22:6(5Z, 8E, 1-0Z, 13Z, 15E, 19Z) 2OH (7s, 17S)/20:4(8Z, 11Z, 14Z, 17Z), PS (21:0/18:0), 3-(4-Met-hyl-3-pentenyl)thiophene (Table 1)

Starting low and increasing slowly makes a substantial difference in tolerability

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