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ROR = 1.13, 95% CI 1.021.25) Lactic acidosis (n = 567

Patients should contact their GP, NHS 111, or healthcare provider if they experience any of the following: Severe or worsening itching that does not improve with simple measures or persists for more than 4872 hours Extensive redness, swelling, or warmth at the injection site, which may indicate cellulitis or another bacterial skin infection Development of a rash that spreads beyond the immediate injection site, particularly if accompanied by systemic symptoms Pain or tenderness that is disproportionate to the expected discomfort from a subcutaneous injection Discharge, pus, or bleeding from the injection site, suggesting possible infection or abscess formation Fever, chills, or malaise occurring in conjunction with injection site symptoms, which may indicate systemic infection or hypersensitivity Signs of a serious allergic reaction require immediate emergency attention

Excli J (2018) 17:25772

Como dermatlogos debemos sospechar su uso ante la transformacin o la aparicin de nevos melanocticos de forma eruptiva, sobre todo en individuos con un intenso bronceado para su fototipo de piel o la poca del ao en que nos encontremos

"If all you care about is how you look, then it's worth using sun protection every day," Ms Chin Fat said.