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It has also been reported that peripherally produced leptin can bind to leptin receptors that are expressed in ependymal cells, crossing the ependymal barrier

At the same time, the study also found that Polyphyllin III treatment induced a protective upregulation of xcT, a negative regulator of ferroptosis

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These are not secondary curiosities for patients with obesity who also live with hypertension, dyslipidaemia, or elevated inflammatory markers, systemic risk reduction may be as clinically important as the weight loss itself

Data were extracted by two investigators separately, and only the RCTs were included in the quantitative synthesis